Publications

2023

AP Mutvei*, MJ Nagiec, John Blenis*. Balancing lysosome abundance in health and disease. Nature Cell Biology. 2023 Aug 14. doi: 10.1038/s41556-023-01197-7. Online ahead of print. PMID:36965617. * corresponding authors

YH Ibrahim, S Pantelios, AP Mutvei. An affinity tool for the isolation of endogenous activem mTORC1 from various cellular sources. Journal of Biological Chemistry.

2023 May;299(5):104644. PMID:35577075

2022

GR Buel, HQ Dang, JM Asara, J Blenis, AP Mutvei. Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1. Journal of Biological Chemistry. 2022 Jun;298(6):102030. PMID:35577075.

Ana P Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B Nunes, Bethany E Schaffer, Anders P Mutvei, John M Asara, Lewis C Cantley, Sarah-Maria Fendt, John Blenis. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature Metabolism. 2022 Apr;4(4):435-443. doi: 10.1038/s42255-022-00553-5.

2020

AP Mutvei*, MJ Nagiec, JC Hamann, SG Kim, CT Vincent, J Blenis*. Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Nature Communications. 2020 Mar 17;11(1):1416. doi: 10.1038/s41467-020-15156-5. * corresponding authors

Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt S-M, Blenis J. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020 Aug 19. PMID:32814897.

2019

Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. PMID:31564638; 

L He, DL Fei, MJ Nagiec, AP Mutvei, A Lamprakis, BY Kim, J Blenis. Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin. Proceedings of the National Academy of Sciences. 116 (39), 19523-19529. PMID:31492813

2018

Anders P Mutvei, Sebastian K-J Landor, Rhys Fox, Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Cecilia Sahlgren, Johan Hartman, Jonas Bergh, Shaobo Jin, Urban Lendahl. Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types. Oncogene. 37 (46), 6083-6095. PMID:29993038

Haiying Zhang, Daniela Freitas, Han Sang Kim, Kristina Fabijanic, Zhong Li, Haiyan Chen, Milica Tesic Mark, Henrik Molina, Alberto Benito Martin, Linda Bojmar, Justin Fang, Sham Rampersaud, Ayuko Hoshino, Irina Matei, Candia M Kenific, Miho Nakajima, Anders Peter Mutvei, Pasquale Sansone, Weston Buehring, Huajuan Wang, Juan Pablo Jimenez, Leona Cohen-Gould, Navid Paknejad, Matthew Brendel, Katia Manova-Todorova, Ana Magalhães, José Alexandre Ferreira, Hugo Osório, André M Silva, Ashish Massey, Juan R Cubillos-Ruiz, Giuseppe Galletti, Paraskevi Giannakakou, Ana Maria Cuervo, John Blenis, Robert Schwartz, Mary Sue Brady, Héctor Peinado, Jacqueline Bromberg, Hiroshi Matsui, Celso A Reis, David Lyden. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature cell biology 20 (3), 332-343. PMID:29459780

Pre-2018 - click link below